Hydrocodone Without Acetaminophen & 10 Times Stronger Than Vicodin Being Created

Hydrocodone without AcetaminophenFour drug companies are in the process of developing a pain killer that is ten times stronger than Vicodin which contains hydrocodone and acetaminophen. This new drug will the first on the market to contain pure hydrocodone without acetaminophen.

Zogenix has completed three rounds of patient testing, and last week they announced they met with the Food and Drug Administration officials for the final meeting to talk about the upcoming drug application. Zogenix plans to file the drug application in early 2012 and have Zohydro on the market by early 2013.

About Zohydro: Zohydro is a novel, oral, single entity (without acetaminophen) extended-release capsule formulation of hydrocodone bitartrate. When used in high dosages over time, acetaminophen can cause liver toxicity. If approved, Zohydro could be the first single-entity hydrocodone therapy available. Zohydro uses Alkermes’ patented Spheriodal Oral Drug Absorption System (SODAS®) drug delivery technology which serves to enhance the release profile of hydrocodone to provide consistent 12-hour pain relief relative to existing immediate release combination products. Capsule strengths utilized in the Phase 3 studies included 10, 20, 30, 40 and 50 mg capsules.

The other companies that are in the process of making this hydrocodone drug are: Perdue Pharma, Cephalon, and Egalet.

Purdue Pharma and Cephalon are in late-stage trials of their own hydrocodone drugs, according to documents filed with the Food and Drug Administration. In May, Purdue Pharma received a patent applying for extended-release technology to hydrocodone.

Egalet has finished the most preliminary stages of safety testing and could have a product on the market as early as 2015 but they would like to see how the other companies get treated by the FDA before they move forward with producing the drug.

The latest drug tests come as more pharmaceutical companies are getting into the $10 billion-a-year legal market for powerful and addictive opiate narcotics reported by Tennessean. “It’s like the wild west,” said Peter Jackson, co-founder of Advocates for the Reform of Prescription Opioids. “The whole supply-side system is set up to perpetuate this massive unloading of opioid narcotics on the American public.”

This new time released drug raises some fears with hydrocodone addiction becauses users can crush it and get an immediate high. “I have a big concern that this could be the next OxyContin. We just don’t need this on the market,” said April Rovero, president of the National Coalition Against Prescription Drug Abuse.

In 2000, there were 19,221 emergency room visits as a result of hydrocodone abuse. In 2009 the number increased drastically to 86,258 visits. Between 2003 and 2007 in the state of Florida, hydrocodone caused 910 deaths and contributed to 1,803 others. These figures are according to the DEA.

Hydrocodone side effects can be serious if not used in the correct way. Some hydrocodone side effects include: Anxiety; constipation; diarrhea; dizziness; dry mouth; gas; headache; heartburn; increased sweating; loss of appetite; nausea; nervousness; stomach pain or upset; trouble sleeping; vomiting; weakness.

You should seek medical attention right away if any of these severe side effects from hydrocodone occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody, black, or tarry stools; blurred vision; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; slow or shallow breathing; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

Examples of how severe Hydrocodone addiction has become reported from drug-addiction.com:  An estimated 7 million dosage units were diverted in 1994 and over 11 million in 1997.
In 1998 there were over 56 million new prescriptions written for hydrocodone products and by 2000 there were over 89 million.
From 1990 the average consumption nationwide has increased by 300%. In the same period there has been a 500% increase in the number of Emergency Department visits attributed to hydrocodone abuse with 19,221 visits estimated in 2000.
In 1997, there were over 1.3 million hydrocodone tablets seized and analyzed by the DEA laboratory system.

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5 Comments on "Hydrocodone Without Acetaminophen & 10 Times Stronger Than Vicodin Being Created"

  1. Gary HerteIv ben on this for a week nowr | December 22, 2014 at 3:51 pm | Reply

    Ive been on this for a week now. My pain is from the top of my ass down to my thigh. The pain can occur when sitting down, standing up, trying to walk, lying down.. This doen’t even begin to help. I’ve been on 100% disability from 1996 so I’ve had to deal with pain for a long time. This pain is many times worse then I’ve ever had. Its good for pain no worse than a sever head ache. What’s disappointing is there is no relief. I’ve been on Time released morphine 100mg 3 times a day and adding this I thought as well as my doctor great for break-through pain. Nope. If your pain is hovering around a 8 threw 10 don’t waste your money and time and ask your doctor for something more powerful. Your doctor has to give you the least that works, well, this isn’t it. I’m on 4 a day and unfortunately nothing. I was given this because Dilauded didn’t help. Use your best judgement mow you have this information

  2. I just received a RX for hydrocordone. 10-325, I live in Las Vegas. It was almost impossible to get it. I went to all the chains and some local’s and finally found it at 1 Walgreen but not at 2 other locations. They all said they had no idea when they would get it 2 other pharmacists told me on the phone they weren’t allowed by law to tell me if they had it in stock. What is the deal for someone who has a legit Rx? Why is this medication in such short supply especially in a large city like Las Vegas? The drug companies can only survive by making a product and making a profit on it. If they don’t or can’t deliver it, why advertise it to the medical community I heard in mid Oct it went from a C3 to a C2 and they had to re-label all stock. I’m sure they had lots of leadtime and since mid Oct they haven’t been able to supply the communities?> I think supply and demand is what we’re seeing and less supply causes the price to go up. I think this is the reason,so I hope consumers keep watch and notify the FDA if you see this illegal price fixing taking place.

  3. kenneth griffin | December 15, 2013 at 2:43 pm | Reply

    im upset because im 62 years old and work 12 hr shifts 5 days a week back to back on slow weeks its 4 ten hour shifts.but my hydro were cut from 7.5/500 to 7.5/325 and I have my own insurance and pay for my own medicine.what give the government the right to cut my medication when its none of their business?i have cronic arthritis pain and if anything I think I need my med upgrade to higher dosage

  4. Finally!! A medication for those who only hydrocodone works for . . . WITHOUT THE LIVER DESTRUCTION of “Tylenol” which never has worked for some folks anyway (like me)! I am livid over having to put my liver in peril, because someone else chooses to abuse Vicodin, etc. Punishing old or injured people with severe/chronic pain, because of those who simply want to get high, is a crime against good honest people!

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